The Rodent Forced Swim Test Measures Stress-Coping Strategy, Not Depression-like Behavior
نویسندگان
چکیده
منابع مشابه
Immobility stress induces depression-like behavior in the forced swim test in mice: effect of magnesium and imipramine.
Previously, we demonstrated antidepressant-like effect of magnesium (Mg) in the forced swim test (FST). Moreover, the joint administration of Mg and imipramine (IMI) at ineffective doses per se, resulted in a potent reduction in the immobility time in this test. In the present study, we examined the effect of immobility stress (IS), and Mg and/or IMI administration on FST behavior. IS induced e...
متن کاملThe Relationship between Depression Potential and Coping Strategy with Stress
چکیده پژوهش: در این پژوهش رابطه بین تمایلات افسردگی و شیوه های مقابله با فشار روانی در دو گروه دانشجویان افسرده و غیر افسرده دانشکده ادبیات و دانشکده فنی - مهندسی دانشگاه آزاد اسلامی واحد کرج مورد بررسی قرار گرفت . نمونه مورد پژوهش ۲۰۰ نفر از دانشجویان سال چهارم رشته های مختلف دو دانشکده فوق بودند که بوسیله تست افسردگی بک و تست شیوه های مقابله با فشار روانی که بوسیله روجر - جارویس - نجاریان۴ ت...
متن کاملThe mouse forced swim test.
The forced swim test is a rodent behavioral test used for evaluation of antidepressant drugs, antidepressant efficacy of new compounds, and experimental manipulations that are aimed at rendering or preventing depressive-like states. Mice are placed in an inescapable transparent tank that is filled with water and their escape related mobility behavior is measured. The forced swim test is straigh...
متن کاملThe forced swim test as a model of depressive-like behavior.
The goal of the present protocol is to describe the forced swim test (FST), which is one of the most commonly used assays for the study of depressive-like behavior in rodents. The FST is based on the assumption that when placing an animal in a container filled with water, it will first make efforts to escape but eventually will exhibit immobility that may be considered to reflect a measure of b...
متن کاملAntidepressant-Like Effects of Lindera obtusiloba Extracts on the Immobility Behavior of Rats in the Forced Swim Test.
Lindera obtusiloba extracts are commonly used as an alternative medicine due to its numerous health benefits in Korea. However, the antidepressant-like effects of L. obtusiloba extracts have not been fully elucidated. In this study, we aimed to determine whether L. obtusiloba extracts exhibited antidepressant-like activity in rats subjected to forced swim test (FST)-induced depression. Acute tr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: ACS Chemical Neuroscience
سال: 2017
ISSN: 1948-7193,1948-7193
DOI: 10.1021/acschemneuro.7b00042